Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2021 , Vol 27 , Issue 6
Protective and Therapeutic Effect of Quercetin in Hepatotoxicity Induced by Sepsis in Rats
Mevlüt DOĞUKAN1, Murat BIÇAKCIOĞLU2, Mehmet DURAN, Zümrüt DOĞAN3, Bilge AYDIN TÜRK4, Öznur ULUDAĞ1
1Anesthesiology and Reanimation Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEY
2Anesthesiology and Reanimation Department, Balıkesir University Faculty of Medicine, TR-10010 Balıkesir - TURKEY
3Anatomy Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEY
4Pathology Department, Adiyaman University Faculty of Medicine, TR-02100 Adiyaman - TURKEY
DOI : 10.9775/kvfd.2021.26135 Septicemia caused by Gram-negative bacteria is an infection associated with liver dysfunction. Quercetin is a natural flavonoid found in vegetables and fruits and has anti-inflammatory, antioxidant, cytoprotective and antiallergic properties. This research aims to investigate the effects of quercetin on the liver against tissue damage due to sepsis-induced oxidative stress. Thirty-two male rats were used in the study. The animals were randomly divided into 5 groups. Quercetin was dissolved in 20 mg/kg of olive oil daily for 15 days and given through oral gavage. The cecal-ligation sepsis model was applied to the group 3 and group 4. In histopathological evaluation; inflammation involving moderate neutrophils and lymphocytes was observed in most portal areas in the group where sepsis was created (Group 3). In the sepsis group administered quercetin (Group 4) only a few portal areas had a milder inflammation with fewer neutrophils than the sepsis group. There was a significant difference between group 3, 4, and all other groups in ALT and AST values. A significant difference was observed between group 3, 4 and other groups in terms of tissue MDA, GSH levels. It was concluded that quercetin, a powerful antioxidant, can reduce liver damage caused by sepsis and has the potential to be used to help treat sepsis. Keywords : Quercetin, Sepsis, Hepatotoxicity, Rat