Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2018 , Vol 24 , Issue 2
Geriatric Cardiology in Dogs - Part 2: Challenge with HF Therapy in Geriatric Dogs: Adverse Drug Reactions and Comorbidities
Kürşad TURGUT1, Havva SÜLEYMANOĞLU1, Merve ERTAN1, Mehmet Ege İNCE1
1Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Near East Boulevard, 99138, Nicosia - NORTHERN CYPRUS DOI : 10.9775/kvfd.2017.18581 In geriatric dogs, aging-specific changes in cardiovascular physiology, drug metabolism, drug pharmacokinetics and drug tolerance contribute to adverse drug reactions (ADRs). Comorbidities can also cause polypharmacy and thus drug-drug interactions. Adverse drug reactions for ACE inhibitors, β–blockers, furosemide, aldosterone antagonists and digoxin are common. Geriatric cardiology epitomizes the principle that cardiovascular disease is only 1 component of a larger, multidimensional disease state with concomitant geriatric syndromes. Comorbidities (cardiorenal syndrome, hypertension, diabetes mellitus, atherosclerotic disease, metabolic syndrome, obesity, chronic obstructive pulmonary disease and frailty and cognitive dysfunction) are common, aggravate HF, complicate therapy and increase the total heart failure burden. Keywords : Geriatric cardiology, Adverse drug reactions, Comorbidities, Dog