This Journal is indexed and abstracted in
Kafkas Üniversitesi Veteriner Fakültesi Dergisi 2017 , Vol 23 , Issue 3
Evaluation of the Effect of Different Doses of Butaphosphan and Cyanocobalamin Combination in Dairy Cattle with Subclinical Ketosis
ŞAHAL M1, DENİZ A2, VURAL R3, KÜPLÜLÜ Ş3, POLAT İM4, ÇOLAKOĞLU EÇ1, ÖCAL N5, MACUN HC4, PEKCAN M6, OCAK M7
1Department of Internal Medicine, Faculty of Veterinary Medicine, Ankara University, TR-06100 Dışkapı/Ankara - TURKEY
2Bayer Animal Health, Leverkusen - GERMANY
3Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Ankara University, TR-06100 Diskapi/Ankara - TURKEY
4Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Kırıkkale University, TR-71000 Kırıkkale - TURKEY
5Department of Internal Medicine, Faculty of Veterinary Medicine, Kırıkkale University, TR-71000 Kırıkkale - TURKEY
6Department of Biochemistry, Faculty of Veterinary Medicine, Ankara University, TR-06100 Dışkapı/Ankara - TURKEY
7Department of Clinical Research and Biometry, 82049 Pullach, Isartal - GERMANY
DOI : 10.9775/kvfd.2016.16651 This study was conducted to assess the effects of different doses of butaphosphan-cyanocobalamin combination onbody condition score (BCS), betahydroxybutyrate (BHBA) and reproductive parameters in cows with subclinical ketosis (SCK). Holstein-Friesen cows (n=544) were checked for BHBA concentration. Cows with SCK (n=53, BHBA ranging from 1.00 to 3.00 mmol/L) were assigned randomly to receive saline (C0, n=18), 5 mL/100 kg BW (C5, n=18) or 10 mL/100 kg BW (C10, n=17) butaphosphan-cyanocobalamin combination. BHBA concentration was measured on d 0, 10, and 18 relative to treatment application. BCS was evaluated weekly until d 60 postpartum. For reproductive parameters cows were monitored until d 150 postpartum. The median reduction in blood BHBA concentrations was 28, 57, and 75% for C0, C5, and C10, respectively. NEFA and total bilirubin concentrations were significantly decreased in C10 group. The relative median change in BCS as compared to baseline was 17, 12, and 6% for C0, C5, and C10, respectively. Between d 15 and 25 postpartum uterine involution was completed in 44, 83, and 88% of cows in groups C0, C5, and C10, respectively. Interval from calving to first insemination in group C10 was shorter than control group. Overall pregnancy rate was not different among groups. In conclusion butaphosphan-cyanocobalamin combination decreased severity of hyperketonemia, stimulated uterine involution, shortened time to first insemination and increased pregnancy rate. Keywords : Beta hydroxybutyrate, Butaphosphan, Cyanocobalamin, Subclinical ketosis, Reproductive performance